Gigantism - How has the endocrine system gone wrong in these conditions: Diabetes 1, Diabetes 2, Goiters, and Gigantism?

How has the endocrine system gone wrong in these conditions: Diabetes 1, Diabetes 2, Goiters, and Gigantism?

i'm going to try and answer these as well as i can. diabetes 1: pancreatic beta cell death due to autoimmune disease. the cells are responsible for producing insulin. diabetes 2: insulin resistance and the cells do not respond to insulin and therefore sugar can't be taken up and utilised by the cells. not sure about the goiter and gigantism... sorry